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in vivo, it recapitulates core features of exercise mimetics, including increased energy expenditure at thermoneutrality, a lower respiratory exchange ratio (RER) consistent with enhanced lipid oxidation, and improvements in fat mass and hepatic lipid content in obese mice

This subsequent binding stimulates a wide array of physiological pathways such as the release of growth hormone (GH), protecting cardiomyocytes, regulating body weight, and development of the musculoskeletal system